Game Changer in Cosmetics

Explanation on how #Regenere3D works and how effective stem cell
is in this product. E.g., are plant stem cells effective in human skin stem
cells ?

In the course of evolution, plants have developed the ability to produce an
enormous number of secondary metabolites, which are not required in the
primary processes of growth and development but are of vital importance for
their interaction with the environment, for their reproductive strategy and
for their defense mechanisms. They have a wide range of chemical structures
and biological activities, and some tend to be strain specific.

Researchers know that extracts of green tea leaves have a host of health
benefits. Green tea contains a large number of biochemically active
compounds called phenolics that include flavonoids that have anti-cancer,
anti-oxidant and anti-aging properties.

Plant secondary metabolites possess several biological activities such as
anti-mutagenic, anti-carcinogenic, anti-aging, etc. Cell suspension culture
is one of the most effective systems to produce secondary metabolites. It is
possible to increase the phenolic compounds and tocopherols by using callus
stem cell suspension cultures.

But could we get more—and more potent—flavonoids and other active biological
ingredients by growing live cells in the NASA-derived bioreactor instead of
just extracting dead leaves in alcohol ? The answer is yes, especially
because I made two other improvements. One was to pick a species of green
tea, the Chinese mountain tea plant, which grows in a harsh high-altitude
environment, and thus needs to make more potent chemicals to protect itself
from insects, sunlight and pathogens. The second was to use a particular
type of cell—so-called plant callus derived from somatic cells that undergo
dedifferentiation to give rise to totipotent embryogenic cells. These are
like stem cells in their ability to regenerate any part of the entire plant.
The cells don’t just make the flavonoids, they also make growth factors and
other proteins and hormones compounds that promote cell regeneration.

Other skin creams may contain green tea leaves extract, but what really
distinguishes extract that is used in our #Regenere3D skin cream is the
unique 3D environment for callus stem cell culture inside our RWV
bioreactor. Moreover our callus stem cell extract contains unique
combination of phytochemicals with additional biological moieties such as
proteins with enzymatic and growth factor properties, as well as plant mRNA
and regulatory plant microRNAs.

Of course, what consumers really want to know is whether #Regenere3D really
works better than competing products. A more direct and relevant approach
was to test the product on people in clinical trials. That’s the approach we’ve
taken and the results exceeded my expectations. And so far the results have
been even better than we had hoped, with wrinkles disappearing, spots
fading, and skin becoming healthier and more youthful.

However as a scientist, I see even greater potential for our 3D cell culture
technology such as growing everything from human skin patches for burn
victims to a whole variety of other organ cells. For example we can imagine
growing hair follicle stem cells that produce growth factors that may
stimulate new hair growth. We are just at the beginning of harnessing the
power of this space-inspired technology to improve health and wellness – and
the future looks bright indeed.