The main advances in combating disease over 200 years have been better food and clean drinking water. Improved sanitation, less overcrowded and better living conditions also contribute. This is also borne out in published peer reviewed research:

http://mobile.dudamobile.com/site/preventdisease?url=http%3A%2F%2Fpreventdisease.com%2Fnews%2F10%2F102510_vaccines_did_not_save_us.shtml&utm_referrer=http%3A%2F%2Fwww.fhfn.org%2Funvaccinated-children-will-be-healthiest-among-future-generations-studies-and-surveys-predict%2F#2845

More graphs
http://www.vaclib.org/sites/debate/Vaccines.html