I think having three Man City players is definitely a must at the moment. Personally I have Otamendi, Sterling and Silva, but with Silva being out at the moment (serious family issue apparently) I might have to transfer him out...

Also, I really don't like the fixture difficulty ranking (FDR) that the Fantasy Premier League website provides, so I made my own. I posted about it yesterday if you want to check it out. Will probably be of some use to you when making similar posts to this one in the future!