No no advance copy. I see now this article is a meta-analysis. I wrote about one of the studies they clearly analyzed. The results are slightly different, ie they state that Naproxen is worse then Ibuprofen which was not previously reported.
I am not sure yet how I feel about any of these studies.
Yes I think I remember it. That is the problem with research it is never quite finished. I think what we really need is something that quantifies the risk in relation to other factors and like I mention at the end chronic pain may itself up your risk of cardiovascular diseases so we need more information before reading too much into this.
I seem to remember that depression can increase cardiovascular outcomes like MI by a factor of 2-4 times (depending on the exact outcome) and that dwarfs the magnitude of the risk here quite significantly.
chronic pain may itself up your risk of cardiovascular diseases so we need more information before reading too much into this.
This is a good point.
depression can increase cardiovascular outcomes like MI by a factor of 2-4 times (depending on the exact outcome) and that dwarfs the magnitude of the risk here quite significantly.
2.6 fold increase in congestive heart failure occurrence for depression. Would have to look for more to find MI. But yeah seems like many confounding factors.
Thanks for finding that link - yes it is quite striking! Another interesting point is that NSAIDs may be able to treat depression - it is still controversial but I have seen a number of studies that suggest this so would be interesting to examine this interaction.
The hypothesis is that it is based on the idea of depression being caused by a chronic inflammatory process. I seem to remember something in relation to paracetamol (acetaminophen) and depression too and obviously the mechanisms would be similar.
It was published 3 days ago - did you get an advance copy?
time-travel is real, I knew it!
:)
No no advance copy. I see now this article is a meta-analysis. I wrote about one of the studies they clearly analyzed. The results are slightly different, ie they state that Naproxen is worse then Ibuprofen which was not previously reported.
I am not sure yet how I feel about any of these studies.
Yes I think I remember it. That is the problem with research it is never quite finished. I think what we really need is something that quantifies the risk in relation to other factors and like I mention at the end chronic pain may itself up your risk of cardiovascular diseases so we need more information before reading too much into this.
I seem to remember that depression can increase cardiovascular outcomes like MI by a factor of 2-4 times (depending on the exact outcome) and that dwarfs the magnitude of the risk here quite significantly.
This is a good point.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771193/
2.6 fold increase in congestive heart failure occurrence for depression. Would have to look for more to find MI. But yeah seems like many confounding factors.
Thanks for finding that link - yes it is quite striking! Another interesting point is that NSAIDs may be able to treat depression - it is still controversial but I have seen a number of studies that suggest this so would be interesting to examine this interaction.
I've never read anything about Cox inhibition and depression before. Might have to look into that a bit. Seems interesting.
The hypothesis is that it is based on the idea of depression being caused by a chronic inflammatory process. I seem to remember something in relation to paracetamol (acetaminophen) and depression too and obviously the mechanisms would be similar.
Tylenol is functional at inhibiting cox-2 in the CNS so it makes sense that it may help we're depression and inflammation linked.