The big questions that no one has yet found answers to. At least none that stand up to empirical testing... Religion will say that there is no such thing as chance (everything is predestined). Applied mathematics talks about probabilities and chaos theory. I would add variables and constants. Correlations and chains of events, dependencies, conditions... Life is a huge self-contained system. Everything is influenced by everything else, and everyone is both a cause and an effect.
I don't know what it is, a person can get self aware, but he still does the same with the added awareness as well.