On top of what you have to say, how can we ever come to a point at which we are certain that we know all there is to know? Or that even a single thing that we think we know (to be true about the nature of reality) is really true?

We might get to a point where we can predict everything that will ever happen (from the most micro to macro events) with a complex mathematical formula, which one might think proves that we've reached the point of knowing how everything works, only to later discover that we were living in a virtual reality and have effectively only managed to reverse-engineer the math that operates that illusory world.

The problem with "absolute knowledge" is that we have no reference point as to what is "absolutely real", as opposed to what we induce and/or deduce to be real, based on some starting assumptions that are, quite frankly, not provable.

Even waking up from something akin to the Matrix (as depicted in the famous movie with that title) isn't sufficient to prove that we're at the "real layer" (reality), as it's possible that there are multiple, or even endless, such layers (Matrices within Matrices, if you will).

It seems as though the best we can do is concede that we do not know if we're experiencing the "ultimate reality", and whether it's even possible to have such an experience, and try to focus on understanding what appears to be real, which, I suppose, is what we're already doing.

In other words, it's a scientist's nightmare and a philosopher's heaven ;)

Luckily for me, I'm a lover of philosophizing.