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RE: Is Your Brain Too Excited?! Neurodegeneration By Over-Stimulation
What kinds of processes contribute to excitotoxicity?
You are not just talking about thinking too hard, or being a disheveled thinker, right?
Are conditions like chronic pain, nerve and brain damage, or psychological manias and phobias the likely triggers for excitotoxicity.
There is a good deal of talk about this in the dog sport world right now, dogs running "too hot", and games being too hot to engage in frequently.
I'm aware that running hot comes with it's drawbacks, but I'm wondering how serious the chemical action has to be to see deleterious effects.
I'll be following your work. Thanks for sharing.
Excitotoxicity is physiological. While certain psychological things might cause behaviors that could put you at risk, there are far more subtle implications of excitotoxic cell death purely from psychologcial states. There is however, reason to believe that chronic stress can cause mPFC excitotoxicity. I will be writing an article in the near future about one example of this which involves anxiety and fear like behavior causing neurodegeneration via cholinergic modulators in rats, and a current study in humans. Be sure to look out for it!
Oooo... forgot another part of the question.
Is there a difference between hyperactivity in primary vs tertiary processes when it comes to excitotoxicity?
Cholinergic, indeed... :D
Interesting word.
I look forward to it.