Hi tfcoates. My experience tells me that Dextrose Prolotherapy works. I've been doing Prolotherapy for about a decade now and I can say that a great percentage of my patients with joint problems, especially those with osteoarthritis, get better with Prolotherapy. I believe successful treatment requires proper patient selection, patient education, an excellent Prolotherapy technique, orthotics if needed, adjunctive therapies, and a good doctor-patient relationship. Thank you for the question, tfcoates.