People require a lot of energy -- mental and physical. Most peoples' priorities are centered around materialism, vices and narcissism. That's why it's important to make sure you're looking after yourself and your needs, or else those needs might not get taken care of.

You have done your part and if they don't reply, it's on them. The same thing has happened to me and I've slowly branched out to include "non-family" as my family instead of "bugging" my real family.