I remember little of Frankenstein, but I think what I do recall relevant. I very well could be remembering this incorrectly, but here goes. At some point before "he" goes on his violent rampage, he takes shelter in an empty woodshed belonging to a very poor family. He tends them, unseen, by bringing them wood, water and food. He grows to love them deeply and they, without having seen him, appreciate him as well. The time comes for him to be seen but his visage disgusts them so they banish him. I was crushed by this part of the book, as crushed as Frankenstein was.
It is possible to find positive meaning through suffering, I was just talking about this with a friend. Poor Frankenstein and The Joker suffered without ever knowing love (not sure about this regarding Joker) and so the meanings they found were loveless. I'm thinking out loud here.
It is extremely important to reach out with love and compassion to those who are different, so that the meanings they attribute to their reasons for being CAN include the concept of love. Otherwise, we make monsters instead of men.