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RE: Research News: Potential Cancer Treatments Through Inhibiting HER Kinase
The development of resistances is definitely due to mutations ( that's how the process works, as I'm sure you are aware). Unfortunately I am not knowledgeable on the specifics of mutational prevalence of the resistant variants.
I think DNA methylation (or loss of methylation), especially in promoter regions of ABC transporters, also plays a role.
However, it would be nice to find genetic prevalence not only for response, but also for resistance! Ty for your answer.