Tobacco is a medicine
The spirit of the Tobacco plant makes a great sacrifice in taking everyone's negativity and transforming it. Its a sacred plant and has traditionally only been used as a medicine often in ceremony.
This is why the recreational use of the plant could lead to trouble. Its not toxic to someone who uses it to let go of troubles and transform them.
Its advised by those who know to use Hape (Shamanic tobacco snuff) as well with this in mind.