While I hope fervently that you do effect your goals per your efforts, I recommend recognizing that you cannot control others, or external events, and compose a 'plan B' in the event that such things impact your life's work. Having no fallback position caused me no little distress when being all in failed to produce tolerable results.

The concept of Samsara, or attachment to worldly expectations, in Buddhism, is an essential reality check that may prevent extreme distress should the world fail you. It is useful to know that you are profitable to you even if the world deprives you of worldly goods.

We are not the sum of our possessions, but of our actions. Take care to act in ways your principles will find admirable regardless of the outcomes of your actions. Regret for acting counter to our principles is a bitter pill indeed, particularly when the expected benefits of those actions aren't forthcoming.